In the last quarter of the 19th century, following the discovery of Christian Science by Mary Baker Eddy, Christian Science churches began forming in many parts of the United States. In the 1880s, two Chicago students of Mary Baker Eddy came to Columbus to establish Christian Science in this area. The first church was chartered in 1896 and located downtown on East Broad Street.

Interest in Christian Science grew and three more Christian Science churches were established in Columbus, all as branches of The First Church of Christ, Scientist, headquartered in Boston. In 2015, the original downtown church and the branch church established in Clintonville in the 1940s (formerly known as Third Church of Christ, Scientist) joined to form what is now First Church of Christ, Scientist, Columbus.

There are two additional churches in Columbus, one in the campus area and one in Upper Arlington.

To learn more about The First Church of Christ, Scientist in Boston and its healing mission worldwide, visit www.christianscience.com.